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Placebo Effect and Pain - Part 1 | PainSolve
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Updates & Features

Placebo Effect and Pain - Part 1

May 2018

Understanding the placebo effect in clinical trials for painkillers

PainSolve Editorial Team

The placebo response: a hot topic for pain researchers?

The role of the placebo effect has become a focus in pain research due to its potential to reduce separation between the drug and control arms, and so influence the outcome in randomised controlled trials (RCTs).1 In clinical trials of analgesics, failure to demonstrate benefit over placebo has been a common finding over the past years.2 Many potentially effective analgesic compounds have been discarded in early drug development due to a lack of statistically significant reductions in pain reports in RCTs.2 For example, in the past 10 years it has been estimated that over 90% of candidate drugs in development for neuropathic and cancer pain have been discontinued after failing to show superiority compared with placebo.3

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