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Pain Pathways | PainSolve
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Pain Pathways

Functional Omics Approach to Identify Overlapping and Unique Pain Pathways

Here we demonstrate the interactive and integrated disease Pain Pathways Map, which utilises the functional omics approach and demonstrates the similarities and differences between biological pathways in pain indications.

By clicking on one of the 8 pain indications below, you can observe their respective biological pathways. The icons next to the molecules indicate whether the gene/protein is up-regulated or down-regulated in that indication, and by switching between the different pain indications on the map you can see the variety in the different pain indications’ pathways. These pathways impact on the pathophysiological presentation of the pain indication, therefore this allows us to identify overlapping and unique pathways for disease understanding and identification of novel therapeutic interventions. Furthermore, overlapping pathways suggest that similar therapeutic approaches could ultimately be used to treat different pain indications. By utilising this approach, we can gain further insights into the causes of pain indications, bringing the pain field closer to effective precision pain medicine.

To create the Pain Pathways Map, a database of gene-disease associations and regulations in disease tissue was built by compiling data from genomics, proteomics, transcriptomics and miRNA publications. Subsequent pathway analysis was performed using gene set enrichment analysis to develop the Pain Pathways Map. Click here to read an in-depth article about the how the Pain Pathways Map was developed.

If you have any questions regarding this Pain Pathways Map, or if you would like to see more details and are interested in collaborating with us to analyse your own data set, please contact: achim.kless@grunenthal.com.

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