Updates & Features
Central Sensitisation: Involvement In Different Sources Of Pain
September 2019
Dr Emilio Quetglas, The PainSolve Team
In recent years, there have not been many publications on the involvement of peripheral sensitisation on the development and maintenance of central sensitisation, although central sensitisation has been suggested to play a role in almost every chronic painful and other medical conditions.1
Peripheral sensitisation represents a reduction in threshold and an amplification in the responsiveness of nociceptors, that occurs when the peripheral terminals are exposed to inflammatory mediators and damaged tissue and, in consequence, is restricted to the site of tissue injury.2 Peripheral sensitisation certainly contributes to the sensitisation of the nociceptive system and thereby to inflammatory pain hypersensitivity at inflamed sites (primary hyperalgesia). Nevertheless, peripheral sensitisation represents a form of pain elicited by activation of nociceptors, albeit one with a lower threshold due to the increased peripheral transduction sensitivity, and generally requires ongoing peripheral pathology for its maintenance. Peripheral sensitisation appears to play a major role in altered heat but not mechanical sensitivity, which is a major feature of central sensitisation.
Diagnostic Challenges of Small Fibre Neuropathy | PainSolve
Diagnostic Challenges of Small Fibre Neuropathy | PainSolve
References
- Harte SE, Harris RE, Clauw DJ. J Appl Behav Res. 2018;23:e12137.
- Latremoliere A, Woolf CJ. J Pain 2009;10(9):895-926.
- Woolf CJ, Salter MW. Science 2000;288:1765-1769.
- Kosek E, Cohen M, Baron R, et al. Pain, 2016;157(7), 1382–1386.
- Gwilym SE, Keltner JR, Warnaby CE, et al. Arthritis Rheum. 2009;61(9):1226-34.
- Henry NL, Clauw DJ. Breast Cancer Res Treat. 2012;133(2):413-6.
- Phillips K, Clauw DJ. Arthritis Rheum. 2013;65(2):291-302.
- Owens MA, Bulls HW, Trost Z, et al. Pain Med 2016;17, 1452–1464.
- Gwilym SE, Filippini N, Douaud G, et al. Arthritis Rheum. 2010;62(10):2930-40.
- Kosek E, Ordeberg G. Eur J Pain. 2000;4(3):229-38
- Petersen KL, Fields HL, Brennum J, et al. Pain. 2000;88(2):125-33.
- Naleschinski D, Baron R. Curr Pain Headache Rep. 2010;14(3):196-202.
- Gracely RH, Lynch SA, Bennett GJ. Pain 1992;51:175–194.
- Baron R, Hans G, Dickenson AH. Ann Neurol 2013;74:630–636
- Ashmawi HA, Goes-Freire GM. Rev. dor 2016;17(supl 1):S31-4
- IASP Council Adopts Task Force Recommendation for Third Mechanistic Descriptor of Pain [Internet]. Washington DC, USA: International Association for the Study of Pain; c2018 [updated 2017 Nov 14]
- IASP Terminology [Internet]. Washington DC, USA: International Association for the Study of Pain; c2018 [updated 2017 Dec 14]
- Clauw DJ. Pain 2015;156:2115–16.
- Vercellini P, Fedele L, Aimi G, et al. Hum Reprod 2007;22:266–71.
- Woolf CJ. J Appl Biobehavioral Res 2018:e12124.
- Foerster BR, Petrou M, Edden RA, et al. Arthritis Rheum 2012;64:579–83.
- Hampson JP, Reed BD, Clauw DJ, et al. J Pain 2013;14:579–89.
- Harris RE, Clauw DJ, Scott DJ, et al. J Neurosci 2007;27:10000–6.
- Harris RE, Sundgren PC, Craig AD, et al. Arthritis Rheum 2009;60:3146–52.
- Kairys AE, Schmidt-Wilcke T, Puiu T, et al. J Urol 2015;193:131–7.
- Kilpatrick LA, Kutch JJ, Tillisch K, et al. J Urol 2014;192:947–55.
- Kutch JJ, Ichesco E, Hampson JP, et al. Pain 2017;158:1979–91.
- Schrepf A, Harper DE, Harte SE, et al. Pain 2016;157:2217–25.
- Seminowicz DA, Labus JS, Bueller JA, et al. Gastroenterology 2010;139:48–57.e42.
- Clauw DJ. J Clin Psychiatry 2008;69(suppl 2):25–9.
- Harris RE, Napadow V, Huggins JP, et al. Anesthesiology 2013;119:1453–64.
- Levitt AE, Galor A, Chowdhury AR, et al. Mol Pain. 2017;13:1744806917729306.
- Maixner W, Fillingim RB, Williams DA, et al. J Pain, 2016;17(9 Suppl):T93–T107.
- Aaron LA, Buchwald D. Ann Int Med, 2001;134(9), 868–881.
- Hudson JJ, Pope HG. Baillieres Clin Rheumatol, 1994;8(4), 839–856.
- Warren JW, Howard FM, Cross RK, et al. Urology, 2009;73(1), 52–57.
- Tracey I, Bushnell MC. J Pain, 2009;10(11), 1113–1120.
- Williams DA, Clauw DJ. J Pain, 2009;10(8), 777–791.
- Woolf CJ. Pain, 2011;152(3 Suppl), S2–S15.
- Longstreth GF, Hawkey CJ, Mayer EA, et al. Aliment Pharmacol Ther. 2001;15(7):959-64.
- Spiller R, Lam C. J Neurogastroenterol Motil 2012;18:258-268
- Drekonja DM, Johnson JR. Prim Care. 2008;35:345–367.
- Harlow BL, Caron RE, Parker SE, et al. J Womens Health (Larchmt). 2017;26(10):1069-1076.
- Murphy MK, MacBarb RF, Wong ME, et al. Int J Oral Maxillofac Implants 2013; 28 (6): e393-e414.
- Farrar WB, McCarty WL. J Ala Dent Assoc 1979; 63:19–26.
- Johnson NP, Sharpe Timms KL. Hum Reprod 2017; 32 (2): 315-324.