Updates & Features

Diagnostic Challenges of Small Fibre Neuropathy

February 2019

What current research is being conducted to overcome the diagnostic challenges of small fibre neuropathy?

Prof. Páll Karlsson, Aarhus University Hospital

Small fibre neuropathy (SFN) has until recently been a neglected subgroup among patients with neuropathy. SFN has a major impact on quality of life because of the underlying disease and the symptoms. SFN constitutes a heterogeneous group of neuropathies in which there is a selective or predominant damage or dysfunction of the thinly myelinated Aδ-fibres and/or unmyelinated C-fibres. Clinically, the patient usually presents with positive and negative symptoms due to small fibre dysfunction and in some cases cardiovascular, gastrointestinal and urogenital dysfunction due to affection of small fibres innervating these organs.

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