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Updates & Features

Placebo Effect and Pain - Part 2

June 2018

Future directions to minimise ‘false negatives’ in pain trials

PainSolve Editorial Team

Given that there is a measurable placebo response in pain and that the impact of this effect may be increasing over time, there is considerable interest in adapting pain clinical trial methodologies and designs to reduce the likelihood of ‘false negative’ trial outcomes due to large pain reductions in the placebo group.1 Several strategies have been proposed for this (see table 1 below):


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